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Atraumatic Swollen Knee in a Child: An Approach

Jul 22, 2025

The atraumatic swollen knee in the paediatric patient can be a diagnostic challenge. Our goal is to diagnose serious conditions such as septic arthritis and osteomyelitis, whilst avoiding unnecessary arthrocentesis. This is an approach.

Differential Diagnosis of an Acutely Atraumatic Swollen Knee:

  1. Infectious
    1. Septic Arthritis
      1. Staphylococcus species can occur in all age groups
      2. Group B streptococcus is more common in < 3mo, whereas Group A is more common in all other age groups
      3. Haemophilus species occur in < 12 yo
      4. Neisseria gonorrhoeae occur in < 3 mo and > 12 yo
      5. Other infectious causes include:
        1. <3mo: Escherichia coli, other G-ve bacilli, Haemophilus species
        2. >3mo - < 12yo: Streptococcus pneumoniae, Salmonella species, Kingella kingae
        3. >12-18yo: Streptococcus pneumonia, Kingella cinge
    2. Osteomyelitis
    3. Pyomyositis
    4. Septic Bursitis
    5. (Lyme arthritis)- varies according to geographical location
  2. Inflammatory
    1. Juvenile arthritis
    2. Acute Rheumatic Fever
    3. SLE. arthrit
    4. ...

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